Mechanism & research context
MOTS-c is a 16-residue peptide encoded in the mitochondrial 12S rRNA gene, acting as a retrograde mitochondrial-to-nuclear signal. It is used in AMPK-activation and metabolic-adaptation research models. Supplied as lyophilized powder at ≥98% HPLC purity.
Selected studies
"MOTS-c is a 16-amino-acid peptide that regulates insulin sensitivity and metabolic homeostasis, preventing age- and diet-dependent insulin resistance and obesity."
Cell Metabolism — ScienceDirectView study
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Article reflects published preclinical and in-vitro literature..